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Why GLP-1s Became the Biggest Health Story in America A few things converged to make this the health topic of the decade so far: 1

In PROACTIVE, there was no difference in the composite primary outcome of death, non-fatal MI, non-fatal stroke, acute coronary syndrome, endovascular or surgical intervention in the coronary or lower extremity arteries, or amputation above the ankle after a median follow-up of just under 3 years (hazard ratio [HR]: 0.90

The first three to six months after dose reduction carry the highest risk for metabolic relapse

Rapid weight loss reduces the amount of elastin and collagen your body makes